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Analysis of Spontaneous Adverse Events Reports of Measles, Mumps, and Rubella Vaccine
Kulhavá, Jana ; Zimčíková, Eva (advisor) ; Horký, Pavel (referee)
Analysis of Spontaneous Adverse Events Reports of Measles, Mumps, and Rubella Vaccine Author: Jana Kulhavá Supervisor: PharmDr. Eva Zimčíková, Ph.D. Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Social and Clinical Pharmacy Keywords: vaccination, measles, mumps, rubella, adverse events reports Introduction: The MMR vaccine is a combined vaccine used to vaccinate children against measles, mumps and rubella. Spontaneous reporting of adverse reactions is an important source of information to identify potential risks of medicinal products. Objective: The aim of this diploma thesis is the analytical evaluation of spontaneous reports of suspected adverse reactions after vaccination with MMR vaccine registered in the database of the State Institute for Drug Control during the period 2004 to 2017. Methods: The data were analyzed in Microsoft Excel spreadsheet software using descriptive statistics methods. The reported adverse reactions were classified into appropriate organ system classes according to the MedDRA Glossary of Medical Terminology. The expectability and severity of adverse reactions were assessed. Results: A total of 805 cases of suspected adverse reactions were reported between 2004 and 2007, which included 2,812 adverse reactions. Most suspected adverse...
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Analysis of Spontaneous Adverse Events Reports of Measles, Mumps, and Rubella Vaccine
Kulhavá, Jana ; Zimčíková, Eva (advisor) ; Horký, Pavel (referee)
Analysis of Spontaneous Adverse Events Reports of Measles, Mumps, and Rubella Vaccine Author: Jana Kulhavá Supervisor: PharmDr. Eva Zimčíková, Ph.D. Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Social and Clinical Pharmacy Keywords: vaccination, measles, mumps, rubella, adverse events reports Introduction: The MMR vaccine is a combined vaccine used to vaccinate children against measles, mumps and rubella. Spontaneous reporting of adverse reactions is an important source of information to identify potential risks of medicinal products. Objective: The aim of this diploma thesis is the analytical evaluation of spontaneous reports of suspected adverse reactions after vaccination with MMR vaccine registered in the database of the State Institute for Drug Control during the period 2004 to 2017. Methods: The data were analyzed in Microsoft Excel spreadsheet software using descriptive statistics methods. The reported adverse reactions were classified into appropriate organ system classes according to the MedDRA Glossary of Medical Terminology. The expectability and severity of adverse reactions were assessed. Results: A total of 805 cases of suspected adverse reactions were reported between 2004 and 2007, which included 2,812 adverse reactions. Most suspected adverse...
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Mumps among adolescents and young adults.
BÖHMOVÁ, Monika
Objectives of the work The aim of the work was to determine the course of mumps in adolescents and young adults and to map the specifics of nursing care in adolescents and young adults from the point of view of nurses of general practitioners. The following research questions have been chosen: What was the course of mumps in adolescents and young adults? What are the specifics of nursing care in adolescents and young adults from the point of view of nurses of general practitioners? Methods used To supply the necessary information was elected qualitative research using in-depth interviews with patients who have had mumps and nurses working with general practitioners for adults or children and adolescents. Interviews were captured by a recorder, recorded on the phone or written, and processed by direct transcription. Results The rewritten interviews were subjected to detailed analysis by open coding, using the paper and pencil method. From the data analysis, a total of six categories were formed, divided into two groups: Nurse interviews and Interviews with patients with mumps. Categories from interviews with nurses are: Vaccination, Measures in mumps, Mumps course according to nurses. The categories of interviews with mumps patients are: Collaboration with medical staff, Patient information and vaccine used, and Mumps course in patients with mumps. The individual categories are assigned subcategories, which are encoded to important information and all are included and illustrated in the various schemes. Conclusion From interviews with respondents, we found out how mumps had progressed by adolescents and young adults. It was found that half the respondents had more serious complications, but without lasting consequences, just in one case, the hearing remained impaired, the other serious complications after the cure disappeared. For nurses the result showed what are the specifics of nursing care in adolescents and young adults from the point of view of nurses practitioners. In the main issue, all nurses were oriented correctly. We have found that nurses have a minimum of experience with this disease because they have encountered it sporadically in their practice, and they know it only theoretically, although the incidence of mumps has increased in recent years and nurses should gain more experience. This finding may result in insufficient awareness of compliance with all treatment measures. The results obtained suggest that it would be advisable for doctors and their nurses who did not experience this disease to attend an education seminar focused on mumps, their symptoms, treatment, possible complications and anti-epidemic measures, with which the nursing care of mumps is related.
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